Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice
Auteurs : Edith Miville-Godbout [Canada] ; Mélanie Bourque [Canada] ; Marc Morissette [Canada] ; Sara Al-Sweidi [Canada] ; Tara Smith [Canada] ; Asuka Mochizuki [Canada, Japon] ; Vijitha Senanayake [Canada] ; Dushmanthi Jayasinghe [Canada] ; Li Wang [Canada] ; Dayan Goodenowe [Canada] ; Thérèse Di Paolo [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animals, Corpus Striatum (drug effects), Corpus Striatum (metabolism), Disease Models, Animal, Docosahexaenoic Acids (therapeutic use), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Male, Mice, Mice, Inbred C57BL, Parkinson Disease (etiology), Parkinson Disease (prevention & control), Plasmalogens (therapeutic use), Vesicular Monoamine Transport Proteins (metabolism).
- MESH :
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug effects : Corpus Striatum.
- etiology : Parkinson Disease.
- metabolism : Corpus Striatum.
- prevention & control : Parkinson Disease.
- chemical , therapeutic use : Docosahexaenoic Acids, Plasmalogens.
- Animals, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL.
Abstract
Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson’s disease (PD) patients. The present study investigated the hypothesis that augmenting plasmalogens could protect striatal dopamine neurons that degenerate in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in mice, a PD model. First, in a pre-treatment experiment male mice were treated for 10 days with the docosahexaenoic acid (DHA)-plasmalogen precursor PPI-1011 (10, 50 and 200 mg/kg). On day 5 mice received MPTP and were killed on day 11. Next, in a post-treatment study, male mice were treated with MPTP and then received daily for 5 days PPI-1011 (5, 10 and 50 mg/kg). MPTP treatment reduced serum plasmalogen levels, striatal contents of dopamine (DA) and its metabolites, serotonin, DA transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). Pre-treatment with PPI-1011 (10 and 50 mg/kg) prevented all MPTP-induced effects. Positive correlations were measured between striatal DA contents and serum plasmalogen levels as well as striatal DAT and VMAT2 specific binding. Post-treatment with PPI-1011 prevented all MPTP-induced effects at 50 mg/kg but not at lower doses. Positive correlations were measured between striatal DA contents and serum plasmalogen levels as well as striatal DAT and VMAT2 specific binding in the post-treatment experiment. PPI-1011 treatment (10 days at 5, 10 and 50 mg/kg) of intact mice left unchanged striatal biogenic amine contents. These data demonstrate that treatment with a plasmalogen precursor is capable of protecting striatal dopamine markers in an animal model of PD.
Url:
DOI: 10.1371/journal.pone.0151020
PubMed: 26959819
PubMed Central: 4784967
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000154
- to stream Pmc, to step Curation: 000154
- to stream Pmc, to step Checkpoint: 000080
- to stream PubMed, to step Corpus: 000273
- to stream PubMed, to step Curation: 000273
- to stream PubMed, to step Checkpoint: 000273
- to stream Ncbi, to step Merge: 001E94
- to stream Ncbi, to step Curation: 001E94
- to stream Ncbi, to step Checkpoint: 001E94
- to stream Main, to step Merge: 000243
- to stream Main, to step Curation: 000243
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice</title>
<author><name sortKey="Miville Godbout, Edith" sort="Miville Godbout, Edith" uniqKey="Miville Godbout E" first="Edith" last="Miville-Godbout">Edith Miville-Godbout</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bourque, Melanie" sort="Bourque, Melanie" uniqKey="Bourque M" first="Mélanie" last="Bourque">Mélanie Bourque</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Sweidi, Sara" sort="Al Sweidi, Sara" uniqKey="Al Sweidi S" first="Sara" last="Al-Sweidi">Sara Al-Sweidi</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Tara" sort="Smith, Tara" uniqKey="Smith T" first="Tara" last="Smith">Tara Smith</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mochizuki, Asuka" sort="Mochizuki, Asuka" uniqKey="Mochizuki A" first="Asuka" last="Mochizuki">Asuka Mochizuki</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba</wicri:regionArea>
<wicri:noRegion>Chiba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Senanayake, Vijitha" sort="Senanayake, Vijitha" uniqKey="Senanayake V" first="Vijitha" last="Senanayake">Vijitha Senanayake</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jayasinghe, Dushmanthi" sort="Jayasinghe, Dushmanthi" uniqKey="Jayasinghe D" first="Dushmanthi" last="Jayasinghe">Dushmanthi Jayasinghe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goodenowe, Dayan" sort="Goodenowe, Dayan" uniqKey="Goodenowe D" first="Dayan" last="Goodenowe">Dayan Goodenowe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26959819</idno>
<idno type="pmc">4784967</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784967</idno>
<idno type="RBID">PMC:4784967</idno>
<idno type="doi">10.1371/journal.pone.0151020</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000154</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000154</idno>
<idno type="wicri:Area/Pmc/Curation">000154</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000154</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000080</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000080</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000273</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000273</idno>
<idno type="wicri:Area/PubMed/Curation">000273</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000273</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000273</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000273</idno>
<idno type="wicri:Area/Ncbi/Merge">001E94</idno>
<idno type="wicri:Area/Ncbi/Curation">001E94</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E94</idno>
<idno type="wicri:Area/Main/Merge">000243</idno>
<idno type="wicri:Area/Main/Curation">000243</idno>
<idno type="wicri:Area/Main/Exploration">000243</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice</title>
<author><name sortKey="Miville Godbout, Edith" sort="Miville Godbout, Edith" uniqKey="Miville Godbout E" first="Edith" last="Miville-Godbout">Edith Miville-Godbout</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bourque, Melanie" sort="Bourque, Melanie" uniqKey="Bourque M" first="Mélanie" last="Bourque">Mélanie Bourque</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Sweidi, Sara" sort="Al Sweidi, Sara" uniqKey="Al Sweidi S" first="Sara" last="Al-Sweidi">Sara Al-Sweidi</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Tara" sort="Smith, Tara" uniqKey="Smith T" first="Tara" last="Smith">Tara Smith</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mochizuki, Asuka" sort="Mochizuki, Asuka" uniqKey="Mochizuki A" first="Asuka" last="Mochizuki">Asuka Mochizuki</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba</wicri:regionArea>
<wicri:noRegion>Chiba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Senanayake, Vijitha" sort="Senanayake, Vijitha" uniqKey="Senanayake V" first="Vijitha" last="Senanayake">Vijitha Senanayake</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jayasinghe, Dushmanthi" sort="Jayasinghe, Dushmanthi" uniqKey="Jayasinghe D" first="Dushmanthi" last="Jayasinghe">Dushmanthi Jayasinghe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goodenowe, Dayan" sort="Goodenowe, Dayan" uniqKey="Goodenowe D" first="Dayan" last="Goodenowe">Dayan Goodenowe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Phenomenome Discoveries Inc., Saskatoon, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Phenomenome Discoveries Inc., Saskatoon</wicri:regionArea>
<wicri:noRegion>Saskatoon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Pharmacy, Laval University, Quebec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Pharmacy, Laval University, Quebec City</wicri:regionArea>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term>
<term>Animals</term>
<term>Corpus Striatum (drug effects)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Docosahexaenoic Acids (therapeutic use)</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (prevention & control)</term>
<term>Plasmalogens (therapeutic use)</term>
<term>Vesicular Monoamine Transport Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Vesicular Monoamine Transport Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Docosahexaenoic Acids</term>
<term>Plasmalogens</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson’s disease (PD) patients. The present study investigated the hypothesis that augmenting plasmalogens could protect striatal dopamine neurons that degenerate in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in mice, a PD model. First, in a pre-treatment experiment male mice were treated for 10 days with the docosahexaenoic acid (DHA)-plasmalogen precursor PPI-1011 (10, 50 and 200 mg/kg). On day 5 mice received MPTP and were killed on day 11. Next, in a post-treatment study, male mice were treated with MPTP and then received daily for 5 days PPI-1011 (5, 10 and 50 mg/kg). MPTP treatment reduced serum plasmalogen levels, striatal contents of dopamine (DA) and its metabolites, serotonin, DA transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). Pre-treatment with PPI-1011 (10 and 50 mg/kg) prevented all MPTP-induced effects. Positive correlations were measured between striatal DA contents and serum plasmalogen levels as well as striatal DAT and VMAT2 specific binding. Post-treatment with PPI-1011 prevented all MPTP-induced effects at 50 mg/kg but not at lower doses. Positive correlations were measured between striatal DA contents and serum plasmalogen levels as well as striatal DAT and VMAT2 specific binding in the post-treatment experiment. PPI-1011 treatment (10 days at 5, 10 and 50 mg/kg) of intact mice left unchanged striatal biogenic amine contents. These data demonstrate that treatment with a plasmalogen precursor is capable of protecting striatal dopamine markers in an animal model of PD.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name>
</author>
<author><name sortKey="Stern, Mb" uniqKey="Stern M">MB Stern</name>
</author>
<author><name sortKey="Sethi, K" uniqKey="Sethi K">K Sethi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braverman, Ne" uniqKey="Braverman N">NE Braverman</name>
</author>
<author><name sortKey="Moser, Ab" uniqKey="Moser A">AB Moser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bousquet, M" uniqKey="Bousquet M">M Bousquet</name>
</author>
<author><name sortKey="Saint Pierre, M" uniqKey="Saint Pierre M">M Saint-Pierre</name>
</author>
<author><name sortKey="Julien, C" uniqKey="Julien C">C Julien</name>
</author>
<author><name sortKey="Salem, N" uniqKey="Salem N">N Salem</name>
</author>
<author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name>
</author>
<author><name sortKey="Calon, F" uniqKey="Calon F">F Calon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, X" uniqKey="Han X">X Han</name>
</author>
<author><name sortKey="Holtzman, Dm" uniqKey="Holtzman D">DM Holtzman</name>
</author>
<author><name sortKey="Mckeel, Dw" uniqKey="Mckeel D">DW McKeel</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dragonas, C" uniqKey="Dragonas C">C Dragonas</name>
</author>
<author><name sortKey="Bertsch, T" uniqKey="Bertsch T">T Bertsch</name>
</author>
<author><name sortKey="Sieber, Cc" uniqKey="Sieber C">CC Sieber</name>
</author>
<author><name sortKey="Brosche, T" uniqKey="Brosche T">T Brosche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fabelo, N" uniqKey="Fabelo N">N Fabelo</name>
</author>
<author><name sortKey="Martin, V" uniqKey="Martin V">V Martin</name>
</author>
<author><name sortKey="Santpere, G" uniqKey="Santpere G">G Santpere</name>
</author>
<author><name sortKey="Marin, R" uniqKey="Marin R">R Marin</name>
</author>
<author><name sortKey="Torrent, L" uniqKey="Torrent L">L Torrent</name>
</author>
<author><name sortKey="Ferrer, I" uniqKey="Ferrer I">I Ferrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wood, Pl" uniqKey="Wood P">PL Wood</name>
</author>
<author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name>
</author>
<author><name sortKey="Smith, T" uniqKey="Smith T">T Smith</name>
</author>
<author><name sortKey="Ehrmantraut, G" uniqKey="Ehrmantraut G">G Ehrmantraut</name>
</author>
<author><name sortKey="Jin, W" uniqKey="Jin W">W Jin</name>
</author>
<author><name sortKey="Cui, W" uniqKey="Cui W">W Cui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wood, Pl" uniqKey="Wood P">PL Wood</name>
</author>
<author><name sortKey="Smith, T" uniqKey="Smith T">T Smith</name>
</author>
<author><name sortKey="Lane, N" uniqKey="Lane N">N Lane</name>
</author>
<author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name>
</author>
<author><name sortKey="Ehrmantraut, G" uniqKey="Ehrmantraut G">G Ehrmantraut</name>
</author>
<author><name sortKey="Goodenowe, Db" uniqKey="Goodenowe D">DB Goodenowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bharat, S" uniqKey="Bharat S">S Bharat</name>
</author>
<author><name sortKey="Cochran, Bc" uniqKey="Cochran B">BC Cochran</name>
</author>
<author><name sortKey="Hsu, M" uniqKey="Hsu M">M Hsu</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Ames, Bn" uniqKey="Ames B">BN Ames</name>
</author>
<author><name sortKey="Andersen, Jk" uniqKey="Andersen J">JK Andersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karunakaran, S" uniqKey="Karunakaran S">S Karunakaran</name>
</author>
<author><name sortKey="Diwakar, L" uniqKey="Diwakar L">L Diwakar</name>
</author>
<author><name sortKey="Saeed, U" uniqKey="Saeed U">U Saeed</name>
</author>
<author><name sortKey="Agarwal, V" uniqKey="Agarwal V">V Agarwal</name>
</author>
<author><name sortKey="Ramakrishnan, S" uniqKey="Ramakrishnan S">S Ramakrishnan</name>
</author>
<author><name sortKey="Iyengar, S" uniqKey="Iyengar S">S Iyengar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blandini, F" uniqKey="Blandini F">F Blandini</name>
</author>
<author><name sortKey="Armentero, Mt" uniqKey="Armentero M">MT Armentero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davis, Gc" uniqKey="Davis G">GC Davis</name>
</author>
<author><name sortKey="Williams, Ac" uniqKey="Williams A">AC Williams</name>
</author>
<author><name sortKey="Markey, Sp" uniqKey="Markey S">SP Markey</name>
</author>
<author><name sortKey="Ebert, Mh" uniqKey="Ebert M">MH Ebert</name>
</author>
<author><name sortKey="Caine, Ed" uniqKey="Caine E">ED Caine</name>
</author>
<author><name sortKey="Reichert, Cm" uniqKey="Reichert C">CM Reichert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Langston, Jw" uniqKey="Langston J">JW Langston</name>
</author>
<author><name sortKey="Ballard, P" uniqKey="Ballard P">P Ballard</name>
</author>
<author><name sortKey="Tetrud, Jw" uniqKey="Tetrud J">JW Tetrud</name>
</author>
<author><name sortKey="Irwin, I" uniqKey="Irwin I">I Irwin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tieu, K" uniqKey="Tieu K">K Tieu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bove, J" uniqKey="Bove J">J Bove</name>
</author>
<author><name sortKey="Perier, C" uniqKey="Perier C">C Perier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruffoli, R" uniqKey="Ruffoli R">R Ruffoli</name>
</author>
<author><name sortKey="Giambelluca, Ma" uniqKey="Giambelluca M">MA Giambelluca</name>
</author>
<author><name sortKey="Scavuzzo, Mc" uniqKey="Scavuzzo M">MC Scavuzzo</name>
</author>
<author><name sortKey="Pasquali, L" uniqKey="Pasquali L">L Pasquali</name>
</author>
<author><name sortKey="Giannessi, F" uniqKey="Giannessi F">F Giannessi</name>
</author>
<author><name sortKey="Fornai, F" uniqKey="Fornai F">F Fornai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cote, M" uniqKey="Cote M">M Cote</name>
</author>
<author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name>
</author>
<author><name sortKey="Poirier, Aa" uniqKey="Poirier A">AA Poirier</name>
</author>
<author><name sortKey="Aube, B" uniqKey="Aube B">B Aube</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name>
</author>
<author><name sortKey="Dluzen, De" uniqKey="Dluzen D">DE Dluzen</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Cote, M" uniqKey="Cote M">M Cote</name>
</author>
<author><name sortKey="Soulet, D" uniqKey="Soulet D">D Soulet</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Litim, N" uniqKey="Litim N">N Litim</name>
</author>
<author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name>
</author>
<author><name sortKey="Al Sweidi, S" uniqKey="Al Sweidi S">S Al Sweidi</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franklin, Kbj" uniqKey="Franklin K">KBJ Franklin</name>
</author>
<author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grandbois, M" uniqKey="Grandbois M">M Grandbois</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Callier, S" uniqKey="Callier S">S Callier</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Callier, S" uniqKey="Callier S">S Callier</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Grandbois, M" uniqKey="Grandbois M">M Grandbois</name>
</author>
<author><name sortKey="Pelaprat, D" uniqKey="Pelaprat D">D Pelaprat</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kilbourn, M" uniqKey="Kilbourn M">M Kilbourn</name>
</author>
<author><name sortKey="Frey, K" uniqKey="Frey K">K Frey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mankidy, R" uniqKey="Mankidy R">R Mankidy</name>
</author>
<author><name sortKey="Ahiahonu, Pw" uniqKey="Ahiahonu P">PW Ahiahonu</name>
</author>
<author><name sortKey="Ma, H" uniqKey="Ma H">H Ma</name>
</author>
<author><name sortKey="Jayasinghe, D" uniqKey="Jayasinghe D">D Jayasinghe</name>
</author>
<author><name sortKey="Ritchie, Sa" uniqKey="Ritchie S">SA Ritchie</name>
</author>
<author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ginsberg, L" uniqKey="Ginsberg L">L Ginsberg</name>
</author>
<author><name sortKey="Rafique, S" uniqKey="Rafique S">S Rafique</name>
</author>
<author><name sortKey="Xuereb, Jh" uniqKey="Xuereb J">JH Xuereb</name>
</author>
<author><name sortKey="Rapoport, Si" uniqKey="Rapoport S">SI Rapoport</name>
</author>
<author><name sortKey="Gershfeld, Nl" uniqKey="Gershfeld N">NL Gershfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name>
</author>
<author><name sortKey="Cervera, P" uniqKey="Cervera P">P Cervera</name>
</author>
<author><name sortKey="Hirsch, E" uniqKey="Hirsch E">E Hirsch</name>
</author>
<author><name sortKey="Javoy Agid, F" uniqKey="Javoy Agid F">F Javoy-Agid</name>
</author>
<author><name sortKey="Lehericy, S" uniqKey="Lehericy S">S Lehericy</name>
</author>
<author><name sortKey="Raisman, R" uniqKey="Raisman R">R Raisman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hornykiewicz, O" uniqKey="Hornykiewicz O">O Hornykiewicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kish, Sj" uniqKey="Kish S">SJ Kish</name>
</author>
<author><name sortKey="Tong, J" uniqKey="Tong J">J Tong</name>
</author>
<author><name sortKey="Hornykiewicz, O" uniqKey="Hornykiewicz O">O Hornykiewicz</name>
</author>
<author><name sortKey="Rajput, A" uniqKey="Rajput A">A Rajput</name>
</author>
<author><name sortKey="Chang, Lj" uniqKey="Chang L">LJ Chang</name>
</author>
<author><name sortKey="Guttman, M" uniqKey="Guttman M">M Guttman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bomasang Layno, E" uniqKey="Bomasang Layno E">E Bomasang-Layno</name>
</author>
<author><name sortKey="Fadlon, I" uniqKey="Fadlon I">I Fadlon</name>
</author>
<author><name sortKey="Murray, An" uniqKey="Murray A">AN Murray</name>
</author>
<author><name sortKey="Himelhoch, S" uniqKey="Himelhoch S">S Himelhoch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stenvinkel, P" uniqKey="Stenvinkel P">P Stenvinkel</name>
</author>
<author><name sortKey="Diczfalusy, U" uniqKey="Diczfalusy U">U Diczfalusy</name>
</author>
<author><name sortKey="Lindholm, B" uniqKey="Lindholm B">B Lindholm</name>
</author>
<author><name sortKey="Heimburger, O" uniqKey="Heimburger O">O Heimburger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshihara, S" uniqKey="Yoshihara S">S Yoshihara</name>
</author>
<author><name sortKey="Harada, K" uniqKey="Harada K">K Harada</name>
</author>
<author><name sortKey="Ohta, S" uniqKey="Ohta S">S Ohta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishimukai, M" uniqKey="Nishimukai M">M Nishimukai</name>
</author>
<author><name sortKey="Maeba, R" uniqKey="Maeba R">R Maeba</name>
</author>
<author><name sortKey="Yamazaki, Y" uniqKey="Yamazaki Y">Y Yamazaki</name>
</author>
<author><name sortKey="Nezu, T" uniqKey="Nezu T">T Nezu</name>
</author>
<author><name sortKey="Sakurai, T" uniqKey="Sakurai T">T Sakurai</name>
</author>
<author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cartier, Ea" uniqKey="Cartier E">EA Cartier</name>
</author>
<author><name sortKey="Parra, La" uniqKey="Parra L">LA Parra</name>
</author>
<author><name sortKey="Baust, Tb" uniqKey="Baust T">TB Baust</name>
</author>
<author><name sortKey="Quiroz, M" uniqKey="Quiroz M">M Quiroz</name>
</author>
<author><name sortKey="Salazar, G" uniqKey="Salazar G">G Salazar</name>
</author>
<author><name sortKey="Faundez, V" uniqKey="Faundez V">V Faundez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munn, Nj" uniqKey="Munn N">NJ Munn</name>
</author>
<author><name sortKey="Arnio, E" uniqKey="Arnio E">E Arnio</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name>
</author>
<author><name sortKey="Zoeller, Ra" uniqKey="Zoeller R">RA Zoeller</name>
</author>
<author><name sortKey="Liscum, L" uniqKey="Liscum L">L Liscum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wood, Pl" uniqKey="Wood P">PL Wood</name>
</author>
<author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name>
</author>
<author><name sortKey="Smith, T" uniqKey="Smith T">T Smith</name>
</author>
<author><name sortKey="Goodenowe, Db" uniqKey="Goodenowe D">DB Goodenowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perichon, R" uniqKey="Perichon R">R Perichon</name>
</author>
<author><name sortKey="Moser, Ab" uniqKey="Moser A">AB Moser</name>
</author>
<author><name sortKey="Wallace, Wc" uniqKey="Wallace W">WC Wallace</name>
</author>
<author><name sortKey="Cunningham, Sc" uniqKey="Cunningham S">SC Cunningham</name>
</author>
<author><name sortKey="Roth, Gs" uniqKey="Roth G">GS Roth</name>
</author>
<author><name sortKey="Moser, Hw" uniqKey="Moser H">HW Moser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Styger, R" uniqKey="Styger R">R Styger</name>
</author>
<author><name sortKey="Wiesmann, Un" uniqKey="Wiesmann U">UN Wiesmann</name>
</author>
<author><name sortKey="Honegger, Ue" uniqKey="Honegger U">UE Honegger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vartanian, T" uniqKey="Vartanian T">T Vartanian</name>
</author>
<author><name sortKey="Sprinkle, Tj" uniqKey="Sprinkle T">TJ Sprinkle</name>
</author>
<author><name sortKey="Dawson, G" uniqKey="Dawson G">G Dawson</name>
</author>
<author><name sortKey="Szuchet, S" uniqKey="Szuchet S">S Szuchet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Kt" uniqKey="Jones K">KT Jones</name>
</author>
<author><name sortKey="Zhen, J" uniqKey="Zhen J">J Zhen</name>
</author>
<author><name sortKey="Reith, Me" uniqKey="Reith M">ME Reith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hossain, Ms" uniqKey="Hossain M">MS Hossain</name>
</author>
<author><name sortKey="Ifuku, M" uniqKey="Ifuku M">M Ifuku</name>
</author>
<author><name sortKey="Take, S" uniqKey="Take S">S Take</name>
</author>
<author><name sortKey="Kawamura, J" uniqKey="Kawamura J">J Kawamura</name>
</author>
<author><name sortKey="Miake, K" uniqKey="Miake K">K Miake</name>
</author>
<author><name sortKey="Katafuchi, T" uniqKey="Katafuchi T">T Katafuchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Astous, M" uniqKey="D Astous M">M D'Astous</name>
</author>
<author><name sortKey="Mendez, P" uniqKey="Mendez P">P Mendez</name>
</author>
<author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name>
</author>
<author><name sortKey="Garcia Segura, Lm" uniqKey="Garcia Segura L">LM Garcia-Segura</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Youdim, Mb" uniqKey="Youdim M">MB Youdim</name>
</author>
<author><name sortKey="Kupershmidt, L" uniqKey="Kupershmidt L">L Kupershmidt</name>
</author>
<author><name sortKey="Amit, T" uniqKey="Amit T">T Amit</name>
</author>
<author><name sortKey="Weinreb, O" uniqKey="Weinreb O">O Weinreb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q Zhao</name>
</author>
<author><name sortKey="Cai, D" uniqKey="Cai D">D Cai</name>
</author>
<author><name sortKey="Bai, Y" uniqKey="Bai Y">Y Bai</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Japon</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Miville Godbout, Edith" sort="Miville Godbout, Edith" uniqKey="Miville Godbout E" first="Edith" last="Miville-Godbout">Edith Miville-Godbout</name>
</noRegion>
<name sortKey="Al Sweidi, Sara" sort="Al Sweidi, Sara" uniqKey="Al Sweidi S" first="Sara" last="Al-Sweidi">Sara Al-Sweidi</name>
<name sortKey="Bourque, Melanie" sort="Bourque, Melanie" uniqKey="Bourque M" first="Mélanie" last="Bourque">Mélanie Bourque</name>
<name sortKey="Bourque, Melanie" sort="Bourque, Melanie" uniqKey="Bourque M" first="Mélanie" last="Bourque">Mélanie Bourque</name>
<name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name>
<name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name>
<name sortKey="Goodenowe, Dayan" sort="Goodenowe, Dayan" uniqKey="Goodenowe D" first="Dayan" last="Goodenowe">Dayan Goodenowe</name>
<name sortKey="Jayasinghe, Dushmanthi" sort="Jayasinghe, Dushmanthi" uniqKey="Jayasinghe D" first="Dushmanthi" last="Jayasinghe">Dushmanthi Jayasinghe</name>
<name sortKey="Miville Godbout, Edith" sort="Miville Godbout, Edith" uniqKey="Miville Godbout E" first="Edith" last="Miville-Godbout">Edith Miville-Godbout</name>
<name sortKey="Mochizuki, Asuka" sort="Mochizuki, Asuka" uniqKey="Mochizuki A" first="Asuka" last="Mochizuki">Asuka Mochizuki</name>
<name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name>
<name sortKey="Senanayake, Vijitha" sort="Senanayake, Vijitha" uniqKey="Senanayake V" first="Vijitha" last="Senanayake">Vijitha Senanayake</name>
<name sortKey="Smith, Tara" sort="Smith, Tara" uniqKey="Smith T" first="Tara" last="Smith">Tara Smith</name>
<name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
</country>
<country name="Japon"><noRegion><name sortKey="Mochizuki, Asuka" sort="Mochizuki, Asuka" uniqKey="Mochizuki A" first="Asuka" last="Mochizuki">Asuka Mochizuki</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000243 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000243 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4784967 |texte= Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26959819" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |